Synthesis of an acyclic nucleoside analog of highly fluorescent luminarosine |
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| Authors: | Joanna Nowak Zofia Gdaniec |
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| Institution: | a Faculty of Chemistry, Adam Mickiewicz University, Grunwaldzka 6, 60-780 Poznań, Poland
b Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12-14, 61-704 Poznań, Poland |
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| Abstract: | Photoirradiation of 1-{9-(2-acetoxyethoxy)methyl]-9H-purin-6-yl}-pyridinium chloride (1b) in aqueous solution leads to two photoproducts, namely 1-{5-formamido-6-(2-acetoxyethoxy)methylamino]pyrimidin-4-yl}pyridinium chloride (2b) and 1-(6-(acetoxymethyl)-5,5a,6,8-tetrahydrooxazolo4,3-e]purin-4-yl)pyridinium chloride (6), which constitutes a new heterocyclic system. Further, photosensitized irradiation of 2b gave the desired acyclic nucleoside analog of the highly fluorescent luminarosine 3b. |
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