Improved Ritter reaction with CF3-containing oxirane for an access to central units of protease inhibitors |
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| Authors: | Mickael Dos Santos Danièle Bonnet-Delpon |
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| Institution: | Laboratoire BioCIS-CNRS, Faculté de Pharmacie, Univ Paris Sud, rue JB Clément, F-92296 Chatenay-Malabry, France |
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| Abstract: | The influence of fluorinated alcohols on the BF3·Et2O-promoted Ritter type reaction has been investigated. Trifluoroethanol/BF3·Et2O system allowed access to the central unit of protease inhibitors by the ring opening of fluorinated epoxide 2 with various nitriles. |
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| Keywords: | Ritter reaction Protease inhibitors Epoxide Fluorine Fluorinated alcohols |
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