Enantioselective total synthesis of pyrroloquinolone as a potent PDE5 inhibitor |
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Authors: | Nagula Shankaraiah |
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Institution: | Laboratory of Asymmetric Synthesis, Chemistry Institute of Natural Resources, Talca University, Talca, PO Box 747, Chile |
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Abstract: | A concise enantioselective strategy for the synthesis of key PDE5 inhibitor 2 was developed in 5 and 6 steps using asymmetric hydrogenation and one-pot chiral auxiliary approaches, respectively. The synthesis features the use of imine 6 obtained through Bischler-Napieralsky reaction from amide 5. Absolute R configuration was introduced in (+)-7 by asymmetric transfer-hydrogenation reaction with Ru(II) catalyst followed by establishing the tricyclic pyrroloquinalone core using the Winterfeldt oxidation. Another alternative synthetic approach for the introduction of chirality in the molecule employed imine 6 and chloroformates of different chiral auxiliaries, which achieved N-acyliminium ion intermediates that were reduced in situ using PdCl2/Et3SiH protocol. These synthetic routes were applied in the total synthesis of promising male erectile dysfunction (MED) PDE5 inhibitor 1. |
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Keywords: | 5 inhibitor" target="_blank">Phosphodiesterase 5 inhibitor Pyrroloquinolone Enantioselective synthesis Chiral auxiliaries Noyori hydrogenation |
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