Tertiary amine effect: synthesis of some novel spirosubstituted pyrido[2,3-d]pyrimidines |
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| Authors: | Biswajita Baruah |
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| Affiliation: | Medicinal Chemistry Division, North East Institute of Science and Technology, Jorhat 785 006, Assam, India |
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| Abstract: | 5-Formyl-6-tertiaryamino uracils 3 prepared from 6-chloro-5-formyl uracil derivative 1 react with barbituric acids 4 in the presence of base catalyst to afford a novel class of spirosubstituted pyrido[2,3-d]pyrimidines 5 via 1,6-electro-cyclisation in excellent yields. |
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| Keywords: | Uracil Tertiary amine effect Pyrido[2,3-d]pyrimidines 1,6-Electrocyclisation |
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