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2,6-Cyclo-xenicanes from the brown algae Dilophus fasciola and Dilophus spiralis
Authors:Efstathia Ioannou  Amel Ismail  Constantinos Vagias
Affiliation:a Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimiopolis Zografou, Athens 15771, Greece
b Institute of Organic and Pharmaceutical Chemistry, National Hellenic Research Foundation, Vas. Constantinou 48, Athens 11635, Greece
c National Institute of Marine Sciences and Technologies (INSTM), Laboratory of Biodiversity and Marine Biotechnology, 28 rue du 2 Mars 1934, Salammbô 2025, Tunisia
Abstract:Seven new diterpenes, featuring the rare 2,6-cyclo-xenicane skeleton, along with eleven previously reported metabolites were isolated from the organic extracts of the brown algae Dilophus fasciola and Dilophus spiralis. The structure elucidation of the isolated natural products was based on detailed analyses of their spectroscopic data (NMR, MS, IR, UV), whereas the assignment of their relative configurations was assisted by molecular modelling studies.
Keywords:Dilophus fasciola   Dilophus spiralis   2,6-cyclo-Xenicanes   Molecular modelling
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