Rationally designed 4-phenoxy substituted prolinamide phenols organocatalyst for the direct aldol reaction in water |
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| Authors: | Shu-peng Zhang Xiang-kai Fu Shao-dong Fu |
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| Institution: | a College of Chemistry, Sichuan University, Chengdu 610065, People’s Republic of China
b College of Chemistry and Chemical Engineering, Southwest-China University, Research Institute of Applied Chemistry Southwest University, The Key Laboratory of Applied Chemistry of Chongqing Municipality, Chongqing 400715, People’s Republic of China |
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| Abstract: | A rationally designed 4-phenoxy substituted prolinamide phenols as an efficient hydrophobic organocatalyst for direct asymmetric aldol reaction in water has been developed. High yield (up to 99%), diastereoselectivity (up to 99:1), and enantioselectivity (up to 97%) were obtained under optimal condition. The influence of substituent groups on the reactivity of catalysts was studied in detail. |
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| Keywords: | Asymmetric catalysis Organocatalysis Direct aldol reaction Water |
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