Efficient stereoselective synthesis of benzoxazines via copper-catalyzed three-component coupling reactions |
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| Authors: | Xiaobing Xu |
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| Affiliation: | Institute of medicinal chemistry, Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062, PR China |
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| Abstract: | A convenient one-pot synthesis of 1,4-benzoxazines via three-component coupling and subsequent O-cyclization is reported. The present reaction provides an efficient protocol to functionalized 1,4-benzoxazine derivatives in good to high yields from aldehydes, amines and alkynes. Furthermore, the O-annulation process is completely regio- and stereoselective, only the six-membered rings and its Z-isomers were obtained. |
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| Keywords: | Copper catalyst Benzoxazines Three-component couplings One-pot synthesis |
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