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The first total synthesis of aplysamine 6, an inhibitor of isoprenylcysteine carboxy methyltransferase
Authors:Nisar Ullah  Khaled M. Arafeh
Affiliation:Chemistry Department, King Fahd University of Petroleum and Minerals, Dhahran 31261, Saudi Arabia
Abstract:The first total synthesis of aplysamine 6, an inhibitor of isoprenylcysteine carboxy methyltransferase (Icmt), was accomplished in an overall high yielding reaction sequence.
Keywords:Aplysamine 6   Icmt inhibitor   Anticancer drug   Chemoselective acylation
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