Metallic salt promoted radical cyclization of beta-keto carboxamides and their corresponding beta-enamino carboxamides |
| |
Authors: | Cossy Bouzide Leblanc |
| |
Institution: | Laboratoire de Chimie Organique, associe au CNRS, ESPCI, 10 rue Vauquelin, 75231 Paris Cedex 05, France. |
| |
Abstract: | Substituted lactams and spirolactams were obtained by Mn(III)-induced radical cyclization of unsaturated beta-keto carboxamides. Treatment of the corresponding tertiary enamines under similar reaction conditions and in the presence of K(2)CO(3) afforded the same cyclized products but with inversion of diastereoselectivity. The oxidation of optically pure secondary enamines leads to diastereomeric spirolactams in an approximately 3:1 ratio. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|