| 聚(丙交酯-co-乙交酯)/β-磷酸三钙复合物的电纺研究 |
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| 引用本文： | 吴殊斌,姚琛,李新松. 聚(丙交酯-co-乙交酯)/β-磷酸三钙复合物的电纺研究[J]. 高分子学报, 2006, 0(1): 11-15 |
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| 作者姓名： | 吴殊斌 姚琛 李新松 |
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| 作者单位： | 1. 东南大学化工系,南京,210018
2. 东南大学化工系,南京,210018;东南大学生物材料和药物释放实验室,南京,210018 |
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| 基金项目： | 江苏省高技术研究基金(基金号BG2002002)，江苏省社会发展基金(基金号BS2001034)，南京市科学技术基金(基金号200301046)，东南大学防SARS专项基金(基金号FS031902)资助项目 |
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| 摘 要： | 对生物可吸收聚(丙交酯-co-乙交酯)(poly(lactide-co-glycolide),PLGA)与β-磷酸三钙(-βTCP)复合物体系进行了电纺.研究了PLGA的浓度,-βTCP与PLGA比例,加料速度,电压,喷头与接收体之间的距离等因素对电纺过程的影响,制备出纳米纤维膜,并用扫描电镜(SEM)等对纤维膜进行表征.结果表明,电纺溶液浓度越高,或者加料速度越快,纳米纤维的直径越粗.力学实验显示,复合物中-βTCP的含量增加使纳米纤维膜的拉伸强度和杨氏模量下降.
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| 关 键 词： | 电纺 纳米纤维膜 聚(丙交酯-co-乙交酯) β-磷酸三钙 |
| 收稿时间： | 2004-07-27 |
| 修稿时间： | 2004-11-04 |
ELECTROSPINNING OF POLY( LACTIDE- co-GLYCOLIDE)/β-TRICALCIUM PHOSPHATE COMPOSITES |
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| WU Shubin,YAO Chen,LI Xinsong. ELECTROSPINNING OF POLY( LACTIDE- co-GLYCOLIDE)/β-TRICALCIUM PHOSPHATE COMPOSITES[J]. Acta Polymerica Sinica, 2006, 0(1): 11-15 |
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| Authors: | WU Shubin YAO Chen LI Xinsong |
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| Affiliation: | 2 Department of Chemistry and Chemical Engineering, Southeast University, Nanjing 210018;2 Biomaterials and Drug Delivery Laboratories, Southeast University, Nanjing 210018 |
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| Abstract: | The Bioresorbable nanofiber mats of(poly(lactide-co-glycolide)/β-tricalcium) phosphate composites(PLGA/β-TCP) were electrospun.The effects of the most important processing parameters including PLGA solution concentration,β-TCP/PLGA weight ratio,feed rate,voltage,and distance between the tip and the receiver on the composite nanofiber mats were investigated in detail.Then,the composite nanofiber mats were characterized by scanning electron microscopy(SEM),TEM(transmission electron microscopy) and tensile tester.The SEM images showed that the diameters of PLGA/β-TCP nanofibers were increased with the increasing of the concentration of PLGA and feed rate.The results of tensile tests revealed that the tensile strength and Young's modulus of the composite nanofiber mats were lowered with increasing the content of β-TCP. |
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| Keywords: | Electrospinning Nanofiber mats Poly(lactide-co-glycolide) β-Tricalcium phosphate |
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