Enantioselektive Cyclopropanierung von 1,1-Diphenylethylen und Diazoessigester mit Kupfer-Katalysatoren |
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Authors: | Henri Brunner Wolfgang Miehling |
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Affiliation: | (1) Institut für Anorganische Chemie, Universität Regensburg, D-8400 Regensburg, Bundesrepublik Deutschland |
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Abstract: | Copper(II) compounds catalyze the reaction of 1,1-diphenylethylene with diazoacetic acid ethylester. The main product is 2,2-diphenylcyclopropane carboxylic acid ethylester. The formation of the carbene dimerization products fumaric and maleic acid diethylester can be suppressed by the continuous addition of diazoacetic acid ester to 1,1-diphenylethylene.37 optically active ligands, partly new, were combined with copper(II)-acetate to givein-situ-catalysts. In five cases isolated copper complexes were used as catalysts. The best optical inductions in the formation of 2,2-diphenylcyclopro-pane carboxylic acid ethylester with up to 65.6% ee were achieved withSchiff base ligands, which derive from salicylaldehyde and amino alcohols, obtained from amino acid esters and phenylGrignard.Prof. Dr.Karl Schlögl, Universität Wien, mit den besten Wünschen zum 60. Geburtstag gewidmet. |
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Keywords: | Catalytic enantioselective cyclopropanation Copper (II) catalysts Optical induction |
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