| The Synthesis of Podophyllotoxin Derivatives with Macrocyclic Dilactone |
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| 作者姓名： | Min YANG Ning CHEN Xin Fu PAN Bing Chang QIN |
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| 作者单位： | Min YANG; Ning CHEN; Xin Fu PAN; Bing Chang QIN(Department of Chemistry. National Laboratory of Applied Organic Chemistry，Lanzhou University，Lanzhou，730000)(Department of chemistry，Anyang Teachers College. Anyang 455002) |
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| 摘 要： | Podophyllotoxin1andmanyofitsderivatives,includingC-2epimer,picropodophyllin2.areantimitoticagents'.Thesemi'syntheticderivativesofIetoposide(VP-16-213)andteniposide(VM-26)areinclinicaluseasanti-canceragents'.SomeanaloguesofIwithamodifiedlactoneringhavebeensynthesizedandfoundtobestillantimitotic'.therebyindicatingthatthelactoneringisnotrequiredforantimitoticactivityin1.Anjanamurthyetap.ha.esynthesizedaderivativebyenlargingthefive-memberedlactoneringinItoasix-memberedone.Sincethen.however.nos…
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The Synthesis of Podophyllotoxin Derivatives with Macrocyclic Dilactone |
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| Min YANG, Ning CHEN, Xin Fu PAN, Bing Chang QIN.The Synthesis of Podophyllotoxin Derivatives with Macrocyclic Dilactone[J].Chinese Chemical Letters,1999(4). |
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| Authors: | Min YANG Ning CHEN Xin Fu PAN Bing Chang QIN |
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| Abstract: | |
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| Keywords: | Podophyllotoxin derivatives macrocyclic dilactone synthesis |
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