Looking glass inhibitors: L-DMDP, a more potent and specific inhibitor of alpha-glucosidases than the enantiomeric natural product DMDP |
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| Authors: | Yu Chu-Yi Asano Naoki Ikeda Kyoko Wang Mei-Xiang Butters Terry D Wormald Mark R Dwek Raymond A Winters Ana L Nash Robert J Fleet George W J |
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| Affiliation: | Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Mansfield Road, Oxford, UK OX1 3TA. |
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| Abstract: | L-DMDP, prepared from D-gulonolactone, is a highly specific inhibitor of a number of plant and mammalian alpha-glucosidases [between 2 and 4 orders of magnitude more potent than the enantiomeric natural product DMDP] but is not an inhibitor of bacterial and yeast alpha-glucosidases. Additionally N-butyl-DMDP is a potent inhibitor of ceramide-specific glucosyltransferase but N-butyl-L-DMDP shows no inhibition. |
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