| 新型N-[cis-3-(2-氯-3,3,3-三氟丙烯基)-2,2-二甲基环丙烷基羰基]-N'-芳氧乙酰肼的合成与生物活性 |
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| 引用本文： | 蒙柳,石德清.新型N-[cis-3-(2-氯-3,3,3-三氟丙烯基)-2,2-二甲基环丙烷基羰基]-N'-芳氧乙酰肼的合成与生物活性[J].有机化学,2009,29(7). |
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| 作者姓名： | 蒙柳 石德清 |
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| 作者单位： | 华中师范大学化学学院,农药与化学生物学教育部重点实验室,武汉,430079 |
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| 基金项目： | 国家自然科学基金，教育部留学回国人员科研启动基金 |
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| 摘 要： | 为了寻找高效、低毒的农药先导化合物,利用cis-3-(2-氯-3,3,3-三氟丙烯基)-2,2-二甲基环丙烷酰氯(1)与芳氧乙酰肼的缩合反应,合成了12种未见文献报道的目标化合物,其结构经IR,1H NMR,MS和元素分析测试技术确证.初步的生物活性测定结果表明,部分目标化合物在100 mg/L浓度下对双子叶植物(油菜)显示出良好的除草活性;同时,部分化合物在200 mg/L浓度下对蚕豆蚜虫(Aphis fabas)显示出较好的杀虫活性.
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| 关 键 词： | cis-3-(2-氯-3 3 3-三氟丙烯基)-2 2-二甲基环丙烷羧酸 芳氧乙酸 双酰肼 生物活性 |
Synthesis and Biological Activities of Novel N-[cis-3-(2-Chloro-3,3,3-trifluoropropenyl)-2,2-dimethylcyclopropylcarbonyl]-N'-(aryloxyacetyl)hydrazines |
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| Meng, Liu,Shi, Deqing.Synthesis and Biological Activities of Novel N-[cis-3-(2-Chloro-3,3,3-trifluoropropenyl)-2,2-dimethylcyclopropylcarbonyl]-N'-(aryloxyacetyl)hydrazines[J].Chinese Journal of Organic Chemistry,2009,29(7). |
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| Authors: | Meng Liu Shi Deqing |
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| Abstract: | In order to develop novel lead compounds for agrochemicals with high activity and low toxicity, 12 title compounds were synthesized via the condensation reactions of cis-3-(2-chloro-3,3,3-trifluoropropenyl)-2,2-dimethylcyclopropylcarbonyl chloride (1) with aryloxyacetyl hydrazines, and structurally confirmed by IR, 1H NMR, EI-MS techniques and elemental analyses. Preliminary bioassays indicated that a fraction of the target compounds possessed good herbicidal activity against dicotyledonous plants (Brassica campestris L) at the concerntration of 100 mg/L and insecticidal activity against Aphisfabae at the concerntration of 200 mg/L. |
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| Keywords: | cis-3-(2-chloro-3 3 3-trifluoropropenyl)-2 2-dimethylcyclopropylcarboxylic acid aryloxyacetic acid diacylhydrazine biological activity |
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