Vanadium bromoperoxidase from Delisea pulchra: enzyme-catalyzed formation of bromofuranone and attendant disruption of quorum sensing |
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| Authors: | Sandy Moriah Carter-Franklin Jayme N Martin Jessica D Butler Alison |
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| Institution: | Department of Chemistry & Biochemistry, University of California, Santa Barbara, CA, USA. |
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| Abstract: | Vanadium bromoperoxidase was isolated and cloned from the marine red alga Delisea pulchra. This enzyme catalyzes the bromolactonization of 4-pentynoic acid forming 5E-bromo-methylidenetetrahydro-2-furanone, a compound which is shown herein to inhibit quorum sensing in the engineered reporter strain, Agrobacterium tumefaciens NTL4. |
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