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BODIPY/Nile‐Red‐Based Efficient FRET Pair: Selective Assay of Endoplasmic Reticulum Membrane Fluidity
Authors:Dr. Zhigang Yang  Youngjin Wi  Young‐Min Yoon  Peter Verwilst  Joo Hee Jang  Prof. Tae Woo Kim  Prof. Chulhun Kang  Prof. Jong Seung Kim
Affiliation:1. Department of Chemistry, Korea University, Seoul, Korea;2. Key Laboratory of optoelectronic devices and systems of ministry of education and Guangdong province, College of optoelectronic engineering, Shenzhen University, Shenzhen, China;3. The School of East-West Medical Science, Kyung Hee University, Yongin, Korea
Abstract:We synthesized a boron‐dipyrromethene (BODIPY)/Nile Red hybrid probe capable of selectively recognizing fluidity changes in the endoplasmic reticulum (ER) membrane due to its preferential localization to the ER and strong energy transfer from BODIPY to the Nile Red moiety, emitting only in nonaqueous environments. ER membrane fluidity in HepG2 cells was markedly reduced by a cell model of metabolic syndrome.
Keywords:endoplasmic reticulum  fluorescence  FRET  membrane fluidity  metabolic syndrome
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