Copper‐Catalyzed Direct Sulfoximination of Heteroaromatic N‐Oxides by Dual C−H/N−H Dehydrogenative Cross‐Coupling |
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| Authors: | Hao Yu Carl Albrecht Dannenberg Dr. Zhen Li Prof. Dr. Carsten Bolm |
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| Affiliation: | Institut für Organische Chemie, RWTH Aachen University, Aachen, Germany |
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| Abstract: | A dual C?H/N?H dehydrogenative coupling of quinoline‐type N‐oxides with sulfoximines that leads to N‐(hetero)arylsulfoximines in high yields has been realized by using a catalytic amount of CuBr in air. The method does not require any additional ligand, base, reactivity modifier or oxidant and provides a practical route towards a series of sulfoximidoyl‐functionalized quinolines and derivatives. |
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| Keywords: | copper catalysis dehydrogenative coupling dual C− H/N− H activation quinoline N-oxides sulfoximines |
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