Total Synthesis of (±)‐Englerin A Using An Intermolecular [3+2] Cycloaddition Reaction of Platinum‐Containing Carbonyl Ylide |
| |
| Authors: | Prof. Dr. Hiroyuki Kusama Aoi Tazawa Dr. Kento Ishida Prof. Dr. Nobuharu Iwasawa |
| |
| Affiliation: | 1. Department of Chemistry, Tokyo Institute of Technology, Tokyo, Japan;2. Department of Chemistry, Faculty of Science, Gakushuin University, Tokyo, Japan |
| |
| Abstract: | Total synthesis of (±)‐Englerin A has been achieved starting from γ,δ‐ynone 5 in 14 steps. The key feature of this synthesis is the highly efficient and stereoselective preparation of 8‐oxabicyclo[3.2.1]octane derivative 6 , a core skeleton of Englerin A, based on an inverse electron‐demand [3+2] cycloaddition reaction of the platinum‐containing carbonyl ylide, which was developed in our laboratory. |
| |
| Keywords: | [3+2] cycloaddition carbonyl ylide natural products platinum total synthesis |
|
|
