五内酯E和长南酸的分离与结构 |
| |
引用本文: | 外嘉森,黄梅芬. 五内酯E和长南酸的分离与结构[J]. 化学学报, 1991, 49(5): 502-506 |
| |
作者姓名: | 外嘉森 黄梅芬 |
| |
作者单位: | 中国科学院上海药物研究所,中国科学院上海药物研究所 上海 200031,上海 200031 |
| |
基金项目: | 国家自然科学基金资助的课题 |
| |
摘 要: | 从浙江临安产的长梗南五味子(Kadsura longipedunculata Finet. etGagnep.)根皮中分得2个新三萜化合物: 五内酯E(Schisanlactone E, 1)和长南酸(changnanic acid 2)以及3个已知物: 五内酯B(schisanlactone B,3)、meso-二氢愈创木脂酸(meso-dihydoguaiaretic acid,4)和β-谷甾醇(β-sitosterol,5)。1和2在体外对白血病p-388细胞有明显地抑制作用, IC50分别为1μg/mL和10μg/mL。本文报道其分离、鉴定与结构研究。
|
关 键 词: | 羧酸 萜类化合物 羟基 三萜 异丙烯基 不饱和酯 抗肿瘤药 五内酯 长南酸 五味子科 |
Isolation and structures of schisanlactone E and changnanic acid |
| |
Abstract: | Two new triterpenoid compounds, schisanlactone E (I) and changnanic acid (II), along with three known compounds, schisanlactone B (III), meso-dihydroguaiaretic acid and b-sitosterol, were isolated from the root bark of Kadsura longipedunculata Finet. et Gagnep. indigenous to the Lin-An district in Zhejiang province of China. Their structures were elucidated by spectroscopic studies. In an anticancer screening I and II show significant inhibition of leukemia p-388 cells in vitro (IC50 1 mg/mL and 10 mg/mL resp.). |
| |
Keywords: | CARBOXYLIC ACID TERPENE HYDROXY GROUP TRITERPENE ISOPROPENYL GROUP UNSATURATED ESTERS ANTITUMOR DRUGS SCHISANDRA CHINENSIS |
本文献已被 CNKI 维普 等数据库收录! |
| 点击此处可从《化学学报》浏览原始摘要信息 |
|
点击此处可从《化学学报》下载全文 |