LC and SPE Determination of Chlorophacinone in Corn Grains, Soil and Rat Plasma |
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| Authors: | Moulay-Hassane Guermouche Kamel Bensalah |
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| Institution: | (1) Faculté de Chimie, USTHB, B.P. no 32, El-Alia, Bab-Ezzouar, Alger, Algeria;(2) LNC, Département de Pharmacie, Faculté mixte de Medecine et Pharmacie, Université d’Alger, 2, rue Didouche Mourad, Alger, Algeria |
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| Abstract: | A liquid chromatographic method was used for the analysis of chlorophacinone in corn, soil and rat plasma. Sample preparation
differed from corn, soil and serum. Simple liquid extraction procedures were applied to soil and corn; solid phase extraction
using Oasis HLB cartridges and easy protocol was used for plasma. Liquid chromatography was on X-terra C18 column. The mobile
phase used did not contain ion-pairing reagent, it was constituted with methanol/ammonium bicarbonate (0.01 M, pH = 7), 70/30,
v/v at 1 mL min−1. UV detection was by using photodiode detector operating at 282 nm. Complete validation of the proposed procedure for corn,
soil and serum was made. |
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| Keywords: | Column liquid chromatography Solid phase extraction Corn soil and serum Chlorophacinone |
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