| A new cytotoxic 2-（2-phenylethyl）chromone from Chinese eaglewood |
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| 引用本文： | Jun Liu,;Jiao Wu,;You Xing Zhao,;Yuan Yuan Deng,;Wen Li Mei,;Hao Fu Dai. A new cytotoxic 2-（2-phenylethyl）chromone from Chinese eaglewood[J]. 中国化学快报, 2008, 19(8): 934-936. DOI: 10.1016/j.cclet.2008.05.034 |
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| 作者姓名： | Jun Liu, Jiao Wu, You Xing Zhao, Yuan Yuan Deng, Wen Li Mei, Hao Fu Dai |
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| 作者单位： | a Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China;b State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China |
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| 基金项目： | 国家重点基础研究发展计划(973计划)，Science and Technology Foundation of Chinese Academy of Agricultural Sciences |
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| 摘 要： | A new compound 8-chloro-5,6,7-trihydroxy-2-（3-hydroxy-4-methoxyphenethyl）-5,6,7,8-tetralaydro-4H-chromen-4-one （1） was isolated from the Chinese eaglewood [Aquilaria sinensis （Lour.） Gilg]. Its structure was elucidated on the basis of spectral data. Compound I showed cytotoxicity against human gastric cancer cell line （SGC-7901） in vitro by MTT method with the IC50 value of 14.6 μg/mL.
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| 关 键 词： | 中药 沉香 色酮 细胞毒性 |
A new cytotoxic 2-(2-phenylethyl)chromone from Chinese eaglewood |
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| Jun Liu,Jiao Wu,You Xing Zhao,Yuan Yuan Deng,Wen Li Mei,Hao Fu Dai. A new cytotoxic 2-(2-phenylethyl)chromone from Chinese eaglewood[J]. Chinese Chemical Letters, 2008, 19(8): 934-936. DOI: 10.1016/j.cclet.2008.05.034 |
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| Authors: | Jun Liu Jiao Wu You Xing Zhao Yuan Yuan Deng Wen Li Mei Hao Fu Dai |
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| Affiliation: | a Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China;b State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China |
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| Abstract: | A new compound 8-chloro-5,6,7-trihydroxy-2-(3-hydroxy-4-methoxyphenethyl)-5,6,7,8-tetrahydro-4H-chromen-4-one (1) was isolated from the Chinese eaglewood [Aquilaria sinensis (Lour.) Gilg]. Its structure was elucidated on the basis of spectral data. Compound 1 showed cytotoxicity against human gastric cancer cell line (SGC-7901) in vitro by MTT method with the IC50 value of 14.6 μg/mL. |
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| Keywords: | Chinese eaglewood Aquilaria sinensis Chromone Cytotoxicity |
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