Dynamical response of nanomechanical oscillators in immiscible viscous fluid for in vitro biomolecular recognition |
| |
Authors: | Dorignac Jerome Kalinowski Agnieszka Erramilli Shyamsunder Mohanty Pritiraj |
| |
Institution: | Department of Physics, Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, USA. |
| |
Abstract: | Dynamical response of nanomechanical cantilever structures immersed in a viscous fluid is important to in vitro single-molecule force spectroscopy, biomolecular recognition of disease-specific proteins, and the study of microscopic protein dynamics. Here we study the stochastic response of biofunctionalized nanomechanical cantilever beams in a viscous fluid. Using the fluctuation-dissipation theorem we derive an exact expression for the spectral density of displacement and a linear approximation for resonance frequency shift. We find that in a viscous solution the frequency shift of the nanoscale cantilever is determined by surface stress generated by biomolecular interaction with negligible contributions from mass loading due to the biomolecules. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|