Enhancing 2-iodoxybenzoic acid reactivity by exploiting a hypervalent twist |
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| Authors: | Su Julius T Goddard William A |
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| Institution: | Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA. |
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| Abstract: | A rearrangement of hypervalent bonds, or twisting, proves to be the rate-determining step in the 2-iodoxybenzoic acid (IBX) oxidation of alcohols. From this insight, derived from density functional theory calculations, we explain why IBX oxidizes large alcohols faster than small ones and propose a modification to the reagent predicted to make it more active. |
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