HPLC Determination of Ritodrine Hydrochloride in Pharmaceutical Formulations |
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| Authors: | H D Revanasiddappa B Manju |
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| Institution: | (1) Department of Chemistry, University of Mysore, Manasagangotri, Mysore, 570 006 Karnataka, India;(2) Department of Chemistry, P.E.S. College of Engineering, Mandya, 571401, India |
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| Abstract: | A simple, rapid, and accurate HPLC method is described for the determination of ritodrine hydrochloride (RTH) in both pure form and pharmaceutical formulations. A Hypersil Shendon ODS column with a mobile phase of dibasic phosphate buffer and acetonitrile (75 : 25) and isoxsuprine hydrochloride were used as an internal standard. The flow rate was 1 mL min–1 and the effluent was monitored at 270 nm pH 4.0. The calibration graph is linear in the range 2–30  g mL–1. The proposed HPLC method has been successfully employed for the determination of RTH in Yutopar tablets and injection solutions. |
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