| 芳醛-[5-(3,4,5-三甲氧基苯基)-1,3,4-噻二唑-2-巯基]-乙酰腙衍生物的合成及生物活性研究 |
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| 引用本文： | 陈江,刘芳,宋宝安,杨松,胡德禹,金林红,陈卓,薛伟. 芳醛-[5-(3,4,5-三甲氧基苯基)-1,3,4-噻二唑-2-巯基]-乙酰腙衍生物的合成及生物活性研究[J]. 有机化学, 2008, 28(5): 894-898 |
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| 作者姓名： | 陈江 刘芳 宋宝安 杨松 胡德禹 金林红 陈卓 薛伟 |
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| 作者单位： | 贵州大学精细化工研究开发中心教育部绿色农药与农业生物工程重点实验室,贵阳,550025 |
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| 基金项目： | 国家重点基础研究发展计划(973计划)，国家自然科学基金，教育部跨世纪优秀人才培养计划，贵州省优秀科技人才资助计划 |
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| 摘 要： | 采用活性基团拼接法, 以2-巯基-5-(3,4,5-三甲氧基苯基)-1,3,4-噻二唑为原料, 经硫醚化、肼解、腙化反应合成了8个芳醛-[5-(3,4,5-三甲氧基苯基)-1,3,4-噻二唑-2-巯基]-乙酰腙衍生物, 并经过元素分析, IR, 1H NMR, 13C NMR对其结构进行了确认. 初步生物活性测试表明, 部分化合物具有一定的抑菌生物活性.
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| 关 键 词： | 酰腙衍生物 1,3,4-噻二唑 合成 抑菌活性 |
| 收稿时间： | 2007-07-19 |
| 修稿时间： | 2007-10-12 |
Synthesis and Bioactivity of Arylaldehyde-[5-(3,4,5-Trimethoxy- phenyl)-1,3,4-thiadiazol-2-yl]-thiol Acetyl Hydrazones |
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| CHEN,Jiang,LIU,Fang,SONG,Bao-An,YANG,Song,HU,De-Yu,JIN,Lin-Hong,CHEN,Zhuo,XUE,Wei. Synthesis and Bioactivity of Arylaldehyde-[5-(3,4,5-Trimethoxy- phenyl)-1,3,4-thiadiazol-2-yl]-thiol Acetyl Hydrazones[J]. Chinese Journal of Organic Chemistry, 2008, 28(5): 894-898 |
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| Authors: | CHEN Jiang LIU Fang SONG Bao-An YANG Song HU De-Yu JIN Lin-Hong CHEN Zhuo XUE Wei |
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| Affiliation: | (Key Laboratory of Green Pesticide and Agriculture Bioengineering, Ministry of Education, Research and Development Center for Fine Chemicals, Guizhou University, Guiyang 550025) |
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| Abstract: | Eight arylaldehyde-[5-(3,4,5-trimethoxyphenyl)-1,3,4-thiadiazol-2-yl]-acetyl hydrazone derivatives were synthesized with [5-(3,4,5-trimethoxyphenyl)-1,3,4-thiadiazole-2-thiol as starting material according to substructure link principle, followed by thioetherification, hydrazide reaction and hydrazone reaction. The structures of these compounds were determined by elemental analysis, IR, 1H NMR, and 13C NMR spectra. Bioassay of the title compounds indicated that some of them exhibited moderate antifungal activity. |
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| Keywords: | hydrazone derivative 1,3,4-thiadiazole synthesis antifungal activity |
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