Microbial transformation of deoxyandrographolide by Alternaria alternata AS 3.4578 |
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| Authors: | Xin Xiu-Lan Deng Sha Zhang Bao-Jing Huang Shan-Shan Tian Yan Ma Xiao-Chi An Lei Shu Xiao-Hong Yao Ji-Hong Cui Xun |
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| Affiliation: | Biotechnology Application Center, Beijing Vocational College of Electronic Science and Technology, Beijing 100029, China. |
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| Abstract: | Biotransformation of deoxyandrographolide (1) by Alternaria alternata AS 3.4578 gave five derivatives identified by spectral methods including 2D NMR as the known dehydroandrographolide (2) and 9beta-hydroxy-dehydroandrographolide (3) and the new compounds 9beta-hydroxy-deoxyandrographolide (4), 3alpha,17,19-trihydroxy-8,13-ent-labdadien-15,16-olide (5) and 3-oxo-9beta-hydroxy-deoxyandrographolide (6). |
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