Iminium ion cascade reaction in the total synthesis of (+)-vincadifformine |
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Authors: | Pandey Ganesh C Prasanna Kumara |
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Institution: | Division of Organic Chemistry, National Chemical Laboratory, Pune-411008, India. gp.pandey@ncl.res.in |
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Abstract: | An iminium ion triggered cascade reaction is described in the total synthesis of (+)-vincadifformine by the coupling of 3,3-substituted tetrahydropyridine and indole derivative. The strategy allows simultaneous construction of two new rings, three new sigma bonds, and two new stereogenic centers in one pot with complete stereochemical control. |
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