Terpenoid metabolites from Spongia spp. and their effects on nucleic acid biosynthesis in sea urchin eggs |
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Authors: | Ponomarenko Ludmila P Terent'eva Natalia A Krasokhin Vladimir B Kalinovsky Anatoliy I Rasskazov Valery A |
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Affiliation: | Pacific Institute of Bioorganic Chemistry, FEB RAS, pr. 100 let Vladivostoku, 159, Vladivostok 690022, Russian Federation. ponomarenko@piboc.dvo.ru |
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Abstract: | 19-Norspongia-13(16),14-diene-3-one (1) was isolated for the first time from a natural source, along with a series of known spongiane diterpenoids (2-11) and sesquiterpene (12) from two unidentified species belonging to the genus Spongia. The effects of 1, 4, 5, 8-12 on biosynthesis of nucleic acids and embryonic development of the sea urchin Strongylocentrotus intermedius have been studied. All the compounds inhibit sea urchin embryo development at concentration of 20 microg/mL and above and DNA biosynthesis at the dose of 10 microg/mL. The inhibitory effect of diterpenoids at least partly may be explained by the inhibition of thymidine kinase activity. |
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