| 吐纳麝香合成及工艺优化 |
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| 引用本文： | 吴秀芹,邓瑞雪,刘普,尹卫平.吐纳麝香合成及工艺优化[J].河南科技大学学报(自然科学版),2011,32(3):92-94,98,114. |
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| 作者姓名： | 吴秀芹 邓瑞雪 刘普 尹卫平 |
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| 作者单位： | 河南科技大学,化工与制药学院,河南洛阳471003 |
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| 基金项目： | 国家中小企业技术创新基金项目(10C26214104503) |
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| 摘 要： | 通过改变催化剂的组成和反应时间(70 min),混合催化剂n(无水AlCl3)∶n(浓H2SO4)=10∶1,吐纳麝香中间体1,1,3,4,4,6-六甲基四氢化萘(HMT)的合成产率达到86%;产品通过用无水乙醇饱和溶液低温结晶法,取代了原合成单元操作中的减压精馏和重结晶操作,使吐纳麝香(AHMT)合成总产率达到80%。该技术过程简单,实施方便,有效地降低了产品吐纳麝香的生产成本,实现了对吐纳麝香的合成工艺优化。
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| 关 键 词： | 吐纳麝香 香料合成 反应机理 工艺优化 |
Synthesis and Process Optimization of Tonalide Musk |
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| WU Xiu-Qin,DENG Rui-Xue,LIU Pu,YIN Wei-Ping.Synthesis and Process Optimization of Tonalide Musk[J].Journal of Henan University of Science & Technology:Natural Science,2011,32(3):92-94,98,114. |
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| Authors: | WU Xiu-Qin DENG Rui-Xue LIU Pu YIN Wei-Ping |
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| Institution: | WU Xiu-Qin,DENG Rui-Xue,LIU Pu,YIN Wei-Ping (Chemical Engineering & Pharmaceutics School,Henan University of Science & Technology,Luoyang 471003,China) |
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| Abstract: | By changing the composition of catalyst for a benefited synthesis reaction of an intermediate of 1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronaphthalene(HMT),n(AlCl3)∶ n(H2SO4) =10∶1,with the reaction time 70 min,the yield of HMT was 86%.Tonalide Musk(AHMT) was purified by low temperature crystallization of saturating ethanol solution,which replaced the previously distillation and recrystallization operation.The total yield of perfume production was 80%.The synthestic technology of AHMT is optimized. |
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| Keywords: | Tonalide Musk Perfume synthesis Reaction mechanism Optimization of process |
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