Anti‐Inflammatory Activity of a Novel Acetylene Isolated from the Roots of Angelica tenuissima Nakai |
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| Authors: | Hyun Gyu Choi Hyukjae Choi Jeong‐Hyung Lee Byung Sun Min Jeong Ah Kim |
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| Affiliation: | 1. College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, Korea;2. College of Pharmacy, Yeungnam University, Gyeongsan, Gyeongbuk, Korea;3. College of Natural Sciences, Kangwon National University, Gangwon‐Do, Korea;4. College of Pharmacy, Catholic University of Daegu, Gyeongsan, Korea |
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| Abstract: | Three polyacetylenes, one novel and two known, were isolated from the root of Angelica tenuissima. Using 1H‐ and 13C‐NMR, COSY, HMBC, and HMQC, their structures were found to be (3R,8S)‐heptadeca‐1‐en‐4,6‐diyne‐3,8‐diol ( 1 ), falcarindiol ( 2 ), and oplopandiol ( 3 ). Absolute configurations of compound 1 were established using Mosher's esterification. In addition, the polyacetylenes ( 1 – 3 ) were evaluated for their anti‐inflammatory activity. Compounds 1 and 3 showed potent inhibitory activity against lipopolysaccharide‐induced nitric oxide (NO) production in RAW267.7 macrophage cells with IC50 values of 4.31 and 5.06 μm, respectively. Compound 1 strongly inhibited inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)‐2 in a concentration‐dependent manner. |
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| Keywords: |
Angelica tenuissima
Polyacetylenes
NO
iNOS
COX‐2 |
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