Three New Pregnane Alkaloids from Pachysandra terminalis |
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Authors: | Yun Sun Jin‐Xiong Chen Jian‐Chao Chen Zhong‐Rong Li Lin Zhou Yan Li Ming‐Hua Qiu |
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Affiliation: | 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China;2. +86‐871‐65223327+86‐871‐65223255 |
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Abstract: | Three new pregnane alkaloids, pachystermine C ( 1 ), pachysanamine A ( 2 ), and pachysanamine B ( 3 ), together with four known ones, pachystermine B ( 4 ), pachysamine A ( 5 ), (20S)‐20‐(dimethylamino)‐16α‐hydroxy‐3β‐(3′α‐isopropyl)lactam‐5α‐pregnan‐4‐one ( 6 ), and E‐salignone ( 7 ), were isolated from Pachysandra terminalis. The chemical structures of the new alkaloids were elucidated by spectroscopic methods. All the compounds were evaluated for their inhibitory activities against HL‐60, SMMC‐7721, A‐549, MCF‐7, and SW480 cell lines, some of the compounds showed stronger cytotoxicity for the test cell lines, especially compounds 2 , 3 , and 7 . |
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Keywords: | Pregnane alkaloids Buxaceae
Pachysandra terminalis
Cytotoxicity |
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