Megastigmane Glycosides from Docynia indica and Their Anti‐inflammatory Activities |
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Authors: | Hoang Viet Dung Nguyen Van Bach Trinh Nam Trung Nguyen Xuan Nhiem Bui Huu Tai Phan Van Kiem SeonJu Park Taek Hwan Lee Sun Yeou Kim Seung Hyun Kim |
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Institution: | 1. Vietnam Military Medical University, Hanoi, Vietnam;2. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, Hanoi, Vietnam;3. College of Pharmacy, Yonsei Institute of Pharmaceutical Science, Yonsei University, Incheon, Korea;4. College of Pharmacy, Gachon University, Incheon, Korea;5. +82‐32‐749‐4514 |
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Abstract: | Using various chromatographic methods, three new megastigmane glycosides, docynicasides A – C ( 1 – 3 ) and ten known, (6S,9R)‐vomifoliol 9‐O‐β‐d ‐xylopyranosyl‐(1′′→6′)‐O‐β‐d ‐glucopyranoside ( 4 ), hyperin ( 5 ), quercitrin ( 6 ), quercetin 3‐α‐l ‐arabinofuranoside ( 7 ), naringenin 7‐O‐β‐d ‐glucopyranoside ( 8 ), phloridzin ( 9 ), phloretin 2′‐O‐β‐d ‐xylopyranosyl‐(1→6)‐β‐d ‐glucopyranoside ( 10 ), pinosylvin 3‐O‐β‐d ‐glucopyranoside ( 11 ), tormentic acid ( 12 ), and chlorogenic acid methyl ester ( 13 ) were isolated from the fruits of Docynia indica. Their chemical structures were elucidated by physical and chemical methods. All the isolated compounds were evaluated for the inhibitory activity on NO production in LPS‐stimulated BV2 cells. As the results, compounds 3 – 5 showed significant inhibitory activity on LPS‐stimulated NO production in BV2 cells with the IC50 values ranging from 21.0 to 29.3 μm . |
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Keywords: |
Docynia  indica
Rosaceae Docynicasides A – C Anti‐inflammatory activities |
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