Baeckeins J and K,Two Novel C‐Methylated Biflavonoids from the Roots of Baeckea frutescens and Their Cytoprotective Activities |
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Authors: | Bei‐Xi Jia Ao Jia Chao‐Jie Li Hui‐Qin Zhao Feng‐Xiao Ren Hong‐Min Liu Qiang Wang |
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Institution: | 1. +86‐371‐67781891+86‐371‐67781908;2. Department of Pharmacognosy, College of Pharmacy, Zhengzhou University, Zhengzhou, P. R. China;3. State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, P. R. China;4. Henan Taifeng Pharmaceutical Science and Technology Group Co., Ltd., Zhengzhou, P. R. China;5. +86‐371‐67781905+86‐371‐67781908;6. +86‐25‐83271390+86‐25‐85301528 |
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Abstract: | Baeckea frutescens is an aromatic shrub used as ornamentals and as food flavor spices in the southern part of P. R. China. Two novel C‐methylated biflavonoids named baeckeins J ( 1 ) and K ( 2 ) were isolated from the roots of B. frutescens, which possessed the unique carbon skeleton conjugated of a flavonol and one isoflavanonol molecule via the linkages of C(2)–C(8*) and C(3)–O–C(7*). The structures of compounds 1 and 2 were elucidated by analysis of 1D‐ and 2D‐NMR, and HR‐ESI‐MS spectral data, and the absolute configuration for chiral C‐atoms C(2) and C(3) were assigned by CD spectrometry combined with quantum chemical calculations. In the bioassay, baeckeins J and K exhibited strong cytoprotective effects on H2O2‐induced oxidative cell death in PC12 cells. |
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Keywords: | Myrtaceae
Baeckea  frutescens
C‐Methylated biflavonoid Baeckeins J and K Cytoprotective activity |
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