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CuBr/Et3N‐Promoted Reactions of 2‐Aminobenzamides and Isothiocyanates: Efficient Synthesis of Novel Quinazolin‐4(3H)‐ones |
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| Authors: | Mohammad Mahdavi Mehdi Asadi Mahsa Khoshbakht Mina Saeedi Mohammad Bayat Alireza Foroumadi Abbas Shafiee |
| Affiliation: | 1. Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran;2. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran;3. Department of Chemistry, Imam Khomeini International University, Qazvin, Iran;4. Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran;5. Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran;6. +98‐21‐66406757+98‐21‐66461178 |
| Abstract: | A series of novel quinazolin‐4(3H)‐one derivatives were efficiently synthesized starting from isatoic anhydride. First, reaction of isatoic anhydride and amines in H2O at room temperature afforded 2‐aminobenzamides. Then, CuBr/Et3N promoted reaction of 2‐aminobenzamides and different aryl isothiocyanates in DMF at 80° afforded the title compounds in good yield. |
| Keywords: | 2‐Aminobenzamides Heterocycles Isatoic anhydride Isothiocyanates Quinazolin‐4(3H)‐ones |