Synthesis of monoglucosylated high-mannose-type dodecasaccharide,a putative ligand for molecular chaperone,calnexin, and calreticulin |
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| Authors: | Matsuo Ichiro Wada Megumi Manabe Shino Yamaguchi Yoshiki Otake Keisuke Kato Koichi Ito Yukishige |
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| Affiliation: | RIKEN (The Institute of Physical and Chemical Research), 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan. |
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| Abstract: | Convergent and stereoselective synthetic routes to Man9GlcNAc2 (1b), alpha-Glc1M9GlcNAc2 (2b), and its stereoisomer beta-Glc1M9GlcNAc2 (3) were established. Interaction analysis of 2b with CRT was measured by 1H NMR spectroscopy, and the first NMR-based evidence for the specific binding of CRT to 2b was obtained. |
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