| Extensive Studies on the AIEt3／THF-Promoted Diastereoselective Tandem Rearrangement／Reduction of a-Hydroxy （Amino） Heterocyclopropane： An Efficient Approach to 2-Quaternary 1,3-Diheteroatom Units |
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| 引用本文： | 李心,王保民,赵学智,高栓虎,涂永强,李得润.Extensive Studies on the AIEt3／THF-Promoted Diastereoselective Tandem Rearrangement／Reduction of a-Hydroxy （Amino） Heterocyclopropane： An Efficient Approach to 2-Quaternary 1,3-Diheteroatom Units[J].中国化学,2004,22(10):1177-1182. |
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| 作者姓名： | 李心 王保民 赵学智 高栓虎 涂永强 李得润 |
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| 作者单位： | DepartmentofChemistry＆StateKeyLaboratoryofAppliedOrganicChemistry,LanzhouUniversity,Lanzhou,Gansu730000,China |
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| 摘 要： | A facile and highly diastereoselective method for the construction of 2-quaternary 1,3-amino alcohols and 1,3-diols has been developed on the basis of the AlEt3/THF-promoted tandem rearrangement/reductive reaction of α-hydroxy (amino) aziridines (epoxides). The progressive achievement in this article included that both 2-epimers of the units could be constructed from the initially same substrate. Also a stereochemistry assignment we reported previously was corrected.
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| 关 键 词： | 三乙基铝 级联反应 四氢呋喃 非对映选择性 氨基醇 1 3-二醇 重整反应 还原反应 a-羟基（氨基）杂环丙烷 |
Extensive Studies on the AlEt3/THF‐promoted diastereoselective tandem rearrangement/reduction of α‐Hydroxy (amino) heterocyclopropane: An efficient approach to 2‐quaternary 1,3‐diheteroatom units |
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| Xin Li,Bao‐Min Wang,Xue‐Zhi Zhao,Shuan‐Hu Gao,Yong‐Qiang Tu,De‐Run Li.Extensive Studies on the AlEt3/THF‐promoted diastereoselective tandem rearrangement/reduction of α‐Hydroxy (amino) heterocyclopropane: An efficient approach to 2‐quaternary 1,3‐diheteroatom units[J].Chinese Journal of Chemistry,2004,22(10):1177-1182. |
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| Authors: | Xin Li Bao‐Min Wang Xue‐Zhi Zhao Shuan‐Hu Gao Yong‐Qiang Tu De‐Run Li |
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| Abstract: | A facile and highly diastereoselective method for the construction of 2‐quaternary 1,3‐amino alcohols and 1,3‐diols has been developed on the basis of the AlEt3/THF‐promoted tandem rearrangement/reductive reaction of α‐hydroxy (amino) aziridines (epoxides). The progressive achievement in this article included that both 2‐epimers of the units could be constructed from the initially same substrate. Also a stereochemistry assignment we reported previously was corrected. |
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| Keywords: | triethyl aluminium tandem reaction quaternary carbon diastereoselectivity amino alcohol |
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