Study of the in vitro degradation of poly(ethyl glyoxylate) |
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| Authors: | Benjamine Belloncle Hassan Oulyadi |
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| Institution: | a INSA-Rouen, Polymères Biopolymères Surfaces, UMR CNRS 6522, Laboratoire de Matériaux Macromoléculaires, Place Emile Blondel BP08, 76131 Mont-Saint-Aignan cedex, France
b Université de Rouen, COBRA, UMR CNRS 6014, Laboratoire de Résonance Magnétique Nucléaire, 76130 Mont-Saint-Aignan, France |
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| Abstract: | In vitro degradation of poly(ethyl glyoxylate) (PEtG), a functionalised polyacetal, was investigated. First, the thermodynamic polymerization parameters and the ceiling temperature (Tc) were determined (ΔHp = 28 ± 3 kJ mol−1, ΔSp = 98 ± 7 J mol−1 K−1, Tc = 310 ± 4 K). Secondly, PEtG hydrolysis was investigated using potentiometry, weight loss measurements, SEC and 1H NMR. The results show that PEtG is stable for at least 7 days in aqueous media. Then degradation occurs and releases ethanol and glyoxylic acid hydrate as final products. A scheme for the degradation mechanism involving chain scission and ester hydrolysis is proposed. |
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| Keywords: | Polyacetal Ceiling temperature Degradation In vitro hydrolysis 1H NMR GPC |
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