Stability of Boolean and continuous dynamics |
| |
Authors: | Ghanbarnejad Fakhteh Klemm Konstantin |
| |
Affiliation: | Bioinformatics Group, Institute for Computer Science, University of Leipzig, H?rtelstra?e 16-18, D-04107 Leipzig, Germany. fakhteh@bioinf.uni-leipzig.de |
| |
Abstract: | Regulatory dynamics in biology is often described by continuous rate equations for continuously varying chemical concentrations. Binary discretization of state space and time leads to Boolean dynamics. In the latter, the dynamics has been called unstable if flip perturbations lead to damage spreading. Here, we find that this stability classification strongly differs from the stability properties of the original continuous dynamics under small perturbations of the state vector. In particular, random networks of nodes with large sensitivity yield stable dynamics under small perturbations. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|