Palladium-catalyzed amination of aryl bromides with hindered N-alkyl-substituted anilines using a palladium(I) tri-tert-butylphosphine bromide dimer |
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| Authors: | Prashad Mahavir Mak Xiao Yin Liu Yugang Repic Oljan |
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| Institution: | Process Research and Development, Chemical and Analytical Development, Novartis Institute for Biomedical Research, One Health Plaza, East Hanover, New Jersey 07936, USA. mahavir.prashad@pharma.novartis.com |
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| Abstract: | An efficient palladium-catalyzed amination of aromatic bromides with hindered N-alkyl-substituted anilines is described, either using the combination of Pd(OAc)(2) and P(t-Bu)(3) or a palladium(I) tri-tert-butylphosphine bromide dimer, Pd(mu-Br)(t-Bu(3)P)](2), a new, commercially available, and easily handled catalyst. |
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