Determination of aromatic amine mutagens,PBTA-1 and PBTA-2, in river water by solid-phase extraction followed by liquid chromatography-tandem mass spectrometry |
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Authors: | Moriwaki Hiroshi Harino Hiroya Hashimoto Hiroyuki Arakawa Ryuichi Ohe Takeshi Yoshikura Taro |
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Institution: | Osaka City Institute of Public Health and Environmental Sciences, 8-34, Tojo-cho, Tennoji-ku, Osaka 543-0026 Japan. moriwaki@oct.zaq.ne.jp |
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Abstract: | We describe a novel method for the determination of two kinds of aromatic amine mutagens, 2-2-(acetylamino)-4-bis(2-methoxyethyl)-amino]-5-amino-7-bromo-4-chloro-2H-benzotriazole (PBTA-1) and 2-2-(acetylamino)-4-bis(2-cyanoethyl)-ethylamino]-5-amino-7-bromo-4-chloro-2H-benzotriazole (PBTA-2), in river water based on liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS-MS). A solid-phase extraction procedure was used for the extraction of PBTA-1 and PBTA-2 from river water. The procedure was rapid and the relative standard deviations were below 4%. The detection limits of PBTA-1 and PBTA-2 in river water using the proposed method were found to be 1 and 2 ng/l, respectively. The compounds were detected by this method in river water taken from two sites in the Yodo River system at the ng/l level. |
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