Synthesis of 2,3-dimorpholino-6-aminoquinoxaline derivatives and application to a new intramolecular fluorescent probe |
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Authors: | Yuriko Matsumura Akira Katoh |
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Affiliation: | Department of Materials and Life Science, Faculty of Science and Technology, Seikei University, 3-3-1 Kitamachi, Kichijoji, Musashino-shi, Tokyo 180-8633, Japan |
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Abstract: | Two fluorescent monomers having a quinoxaline skeleton, N-(2,3-dimorpholinoquinoxalin-6-yl)acrylamide (QxA) and N-(1-(2,3-dimorpholinoquinoxalin-6-ylamino)prop-2-yl)methacrylamide (QxAlaMA), were synthesized. Thermo-responsive copolymers of N-isopropylacrylamide (NIPAM) and a small amount of a fluorescent monomer were synthesized and their fluorescence properties investigated. The fluorescent monomers showed intense solvatochromism in their fluorescence. The wavelength at the maximum fluorescence intensity of the QxAlaMA-labeled PNIPAM dramatically blue-shifted and the fluorescence intensity of the QxA-labeled PNIPAM significantly increased around the transition temperature. It was found that these fluorescent dyes can sense and report the thermo-responsive behavior of the PNIPAM in water. Both QxAlaMA and QxA were demonstrated to be applicable to new intramolecular fluorescent probes. |
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Keywords: | 32.50.+d 68.18.JK 82.50.&minus m |
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