Synthesis of novel nithiazine analogues containing the 1,4-dihydropyridine structure,and their bioactivity as insecticides |
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| Authors: | Zhongzhen Tian Shuxia Cui Zhiping Xu |
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| Institution: | 1. Shandong Provincial Key Laboratory of Fluorine Chemistry and Chemical Materials, School of Chemistry and Chemical Engineering, University of Jinan, 106 Jiwei Road, Jinan, 250022, People’s Republic of China
2. Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, People’s Republic of China
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| Abstract: | A series of novel nithiazine analogues bearing the 1,4-dihydropyridine structure have been designed and synthesized by reaction of nithiazine, malononitrile or ethyl cyanoacetate, and benzaldehyde. The synthesized compounds were identified by 1H NMR and IR spectroscopy, and elemental analysis. Preliminary bioassays indicated that most of the compounds had moderate insecticidal activity against Aphis craccivora. The relationship between molecular structure and biological activity is discussed. |
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