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Catalytic multicomponent cycloaddition assembling three different substances to form highly substituted bicyclo[4.2.0]octanes |
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| Authors: | Kiyosei Takasu Kazato Inanaga |
| Institution: | a Graduate School of Pharmaceutical Sciences, Kyoto University, Shimoadachi-cho, Yoshida, Kyoto 606-8501, Japan b Graduate School of Pharmaceutical Sciences, Tohoku University, Aobayama, Sendai 980-8578, Japan c The Faculty of Pharmaceutical Science, Hoshi University, 2-4-41 Ebara, Shinagawa, Tokyo 142-8501, Japan |
| Abstract: | A catalytic multicomponent (4+2)-(2+2) cascade cycloaddition process assembling three different substances has been developed. The process is able to rapidly provide a highly substituted bicyclo4.2.0]octane skeleton from a 2-siloxydiene and two molecules of α,β-unsaturated carbonyl partners. The MCR process is accompanied by stereoselective formation of four carbon-carbon bonds and four stereogenic centers in a single operation. |
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