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2-(Trimethylsilyl)ethanesulfonyl amide as a new ammonia equivalent for palladium-catalyzed amination of aryl halides |
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| Authors: | Prakash Anjanappa Kumaravel Selvakumar Manickam Sivakumar |
| Institution: | a Synthetic Chemistry, Syngene International Ltd, Biocon Park, Plot 2 and 3, Jigani Link Road, Bommasandra Industrial Area, Bangalore 560 099, India b Department of Pharmaceutical Engineering and Technology, Bharathidasan Institute of Technology, Bharathidasan University, Tiruchirappalli 620 024, India c School of Chemical and Environmental Engineering, University of Nottingham (Malaysia campus), Semenyih 43500, Malaysia |
| Abstract: | 2-(Trimethylsilyl)ethanesulfonyl amide (SES-NH2) is an ammonia equivalent for the palladium-catalyzed amination of aryl bromides and aryl chlorides. Using these amine derivatives, it has been observed that anilines and anilines with sensitive functional groups can be readily prepared. |
| Keywords: | Palladium catalysis Ammonia surrogates Cross-coupling 2-(Trimethylsilyl)ethanesulfonyl amide |
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