InCl3-assisted one-pot synthesis of 1-aminocarbazoles |
| |
| Authors: | Diego FacoettiGiorgio Abbiati Monica Dell’AcquaElisabetta Rossi |
| |
| Institution: | Dipartimento di Scienze Molecolari Applicate ai Biosistemi (DISMAB)-Sezione di Chimica Organica ‘A. Marchesini’ Università degli Studi di Milano, Via G. Venezian 21, 20133 Milano, Italy |
| |
| Abstract: | A novel InCl3-mediated one-pot reaction leading to 1-aminocarbazoles is reported. Starting from easily available 2-acetyl-1H-indole, the reaction involves the alkylation of C-3 with a prop-2-yn-1-ol followed by a domino aminobenzannulation reaction in the presence of a secondary amine. The indium salt is most likely involved as catalyst in all three steps of the one-pot reaction. Starting from 2-acetyl-1H-indole and a series of prop-2-yn-1-ols and secondary amines a small library of products has been obtained. |
| |
| Keywords: | 1-Amminocarbazoles Indium chloride One-pot reactions Domino reactions Lewis acids |
| 本文献已被 ScienceDirect 等数据库收录！ |
