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Complementary routes for the stereoselective synthesis of functionalized benzoquinolizidine targets |
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| Authors: | Steven M Allin Liam J Duffy Vickie McKee Michael J McKenzie Oriol Bassas Joan Bosch |
| Institution: | a Department of Chemistry, Loughborough University, Loughborough, Leicestershire, LE11 3TU, UK b Laboratory of Organic Chemistry, Faculty of Pharmacy, University of Barcelona, 08028 Barcelona, Spain c Charnwood Molecular Ltd, Heritage Building, Prince William Road, Loughborough LE11 5GA, UK |
| Abstract: | We report new and complementary routes for the highly stereoselective construction of functionalized benzoquinolizidine targets from readily available, non-racemic chiral templates. The methods developed allow us to predetermine relative product stereochemistries by judicious choice of substrate sub-structure, and provide ready access to alternative stereoisomers. |
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