Synthesis of (−)- and (+)-8-fluoro-galanthamine |
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| Authors: | Petr Knesl Kurt Mereiter |
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| Institution: | a Vienna University of Technology, Institute of Applied Synthetic Chemistry, Getreidemarkt 9, 1060 Vienna, Austria
b Vienna University of Technology, Institute of Chemical Technologies and Analytics, Getreidemarkt 9, 1060 Vienna, Austria |
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| Abstract: | The synthesis of racemic 8-fluorogalanthamine and its separation into (−)- and (+)-8-fluorogalanthamine (= (4aS,6R,8aS)- and (4aR,6S,8aR)-1-fluoro-4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6H-benzofuro3a,3,2-ef]2]benzazepin-6-ol) is described. |
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