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Microwave-assisted rapid and straightforward synthesis of 2-aryl-4-quinolones from acylated 2′-aminoacetophenones |
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| Authors: | Derong Ding Xin Wang |
| Affiliation: | State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, PR China |
| Abstract: | The syntheses of a diverse set of 2-aryl-4-quinolone derivatives were achieved by exposing corresponding acylated 2′-aminoacetophenones to microwave irradiation in the presence of NaOH. The microwave accelerated cyclizations were complete within 10-22 min at 120 °C giving 57-95% isolated yields. |
| Keywords: | Microwave-assisted synthesis 2-Aryl-4-quinolone Acylated 2&prime -aminoacetophenone |
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