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Synthetic studies toward macrocidins: an RCM approach for the construction of the central cyclic core |
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| Authors: | CV Ramana Mohabul A Mondal Vedavati G Puranik Mukund K Gurjar |
| Institution: | National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411 008, India |
| Abstract: | The central macrocyclic core of the macrocidins was constructed using RCM as the key reaction. A preliminary investigation dealing with the key reactions, that is, the Dieckmann cyclization and the RCM, revealed that RCM of the β-ketoamide is better than RCM of the corresponding acyltetramic acid. |
| Keywords: | Macrocidins Acyltetramic acid Lacey-Dieckmann cyclization Ring closing metathesis |
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