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Synthesis of 5-aryltriazole ribonucleosides via Suzuki coupling and promoted by microwave irradiation |
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| Authors: | Jinqiao Wan Yi Xia Qiongyou Wu Johan Neyts |
| Affiliation: | a College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, PR China b Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, College of Chemistry, Central China Normal University, PR China c Rega Institute for Medical Research, Minderbroedersstraat 10, B-3000 Leuven, Belgium d CNRS UMR 6114, Département de chimie, 163, avenue de Luminy, 13288 Marseille, France |
| Abstract: | Aryltriazole nucleosides with various aromatic groups in the 5-position on the triazole ring were synthesized and characterized with the aim to develop novel triazole nucleosides. The aromatic groups were introduced into the triazole ring via a Suzuki reaction starting with bromotriazole nucleoside. Microwave irradiation significantly promoted the Suzuki coupling, quickly giving clean products with good to excellent yields. |
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